Hyperbaric chambers, also known as hyperbaric oxygen therapy (HBOT) chambers, have been used for decades to treat a variety of medical conditions. These specialized enclosures utilize increased atmospheric pressure to deliver high concentrations of oxygen to the body, promoting healing, reducing inflammation, and enhancing overall health.
In this article, we will explain the history, principles, and therapeutic applications of hyperbaric chambers, highlighting their uses in various medical fields.

In 1662 Nathaniel Henshaw built the first chamber, called the "domicilium." This early chamber was used to treat various health conditions, but it wasn't until the 19th century that hyperbaric medicine started to gain momentum.
In the 1830s, hyperbaric medicine experienced a revival in Europe with the construction of new chambers and the establishment of "pneumatic centers." One notable chamber was built by Pravaz in Lyon, France, in 1837, which could accommodate 12 patients. This period marked the beginning of hyperbaric medicine as a recognized treatment option.
The modern era of hyperbaric medicine began in the mid-20th century with the work of researchers like Dr. Álvaro Osório de Almeida and Dr. Boerema. Today, hyperbaric oxygen therapy is used to treat a range of medical conditions, including wounds, injuries, and neurological disorders.
The development of hyperbaric medicine continues to evolve, with new technologies and treatments being developed to improve patient outcomes.

A hyperbaric chamber is a pressurized enclosure that maintains a higher atmospheric pressure than the surrounding environment. The chamber is typically filled with 100% oxygen, which is inhaled by the patient through a mask or hood.
The increased pressure allows the oxygen to dissolve more easily into the bloodstream, tissues, and organs, promoting various therapeutic effects.
Hyperbaric oxygen therapy (HBOT) increases the partial pressure of oxygen in the blood, which allows for more oxygen to be delivered to the body's tissues and organs. This is especially beneficial for areas of the body that are not receiving enough oxygen, such as wounds or damaged tissues.
When you breathe in a hyperbaric chamber, the high pressure allows your body to absorb more oxygen than it would at normal air pressure. This extra oxygen is then carried to all parts of your body, helping to heal and repair damaged tissues.
HBOT has anti-inflammatory properties, which can help reduce swelling and promote healing by decreasing the production of pro-inflammatory cytokines and increasing the production of anti-inflammatory cytokines.
When you're injured or sick, your body's natural response is to become inflamed. Hyperbaric oxygen therapy can help reduce this inflammation, which can make you feel better and promote healing.
HBOT enhances wound healing by increasing collagen synthesis, promoting angiogenesis (the formation of new blood vessels), and increasing the production of growth factors that are essential for wound healing.
Hyperbaric oxygen therapy can help your body heal wounds faster and more effectively. The extra oxygen helps to build new tissue, reduce swelling, and promote the growth of new blood vessels, all of which are essential for healing.

Hyperbaric chambers are used to treat a wide range of medical conditions, including:
Hyperbaric oxygen therapy is also used to treat:

Researchers are working on exploring new ways to use hyperbaric chambers to help people with different medical conditions. Some potential future uses include:
Hyperbaric chambers have been used for decades to treat a variety of medical conditions. The therapeutic applications of HBOT are diverse, ranging from wound care and decompression sickness to chronic pain management and infectious diseases. While there are some contraindications and potential side effects, the benefits of hyperbaric chambers make them a valuable tool in modern medicine. As research continues to uncover new applications for HBOT, it is likely that hyperbaric chambers will play an increasingly important role in the treatment of various medical conditions.
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The role of Hyperbaric Oxygen therapy (HBOT) in cancer treatment and management | National Hyperbaric. (n.d.-b). https://www.nationalhyperbaric.com/hbot-treatments-and-conditions/cancer
History of HBO | DDRC Healthcare. (2024c, April 16). DDRC Healthcare. https://www.ddrc.org/hyperbarics/history-of-hbo/
Ahmadi, F., & Khalatbary, A. R. (2021b). A review on the neuroprotective effects of hyperbaric oxygen therapy. Medical Gas Research, 11(2), 72–82. https://doi.org/10.4103/2045-9912.311498